Clinical Study on Heat Shock Protein 70 in Skin Tissue of Patients with Pemphigus by Immunohistochemistry
10.3969/j.issn.1671-7414.2017.03.022
- VernacularTitle:应用免疫组化方法检测天疱疮患者皮肤组织热休克蛋白70的临床研究
- Author:
Fang HUANG
;
Yaofeng JIN
;
Jie LU
;
Sipeng LI
;
Ting ZHANG
;
Yiguo FENG
;
Jinghong CHEN
;
Yan GENG
- Keywords:
pemphigus;
heat shock protein 70;
pathogenesis
- From:
Journal of Modern Laboratory Medicine
2017;32(3):82-85
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study was performed to investigate the levels of HSP70 in tissue in pemphigus as a possible new theoretical basis for further elucidate the pathogenesis of pemphigus.Methods The expression of HSP70 in 62 patients with pemphigus was determined by immunohistochemistry,and the normal skin was taken as control.Results The results showed that the positive cells of HSP70＞75 ％ in the blisters of pemphigus vulgaris and the positive cells of HSP70＞50％ in the inflammatory cells near the blisters,and the expression of HSP70 was significantly higher than that in normal skin,which was statistically significant(Z=5.42,4.73,P＜0.01).Conclusion The abnormal expression of HSP70 in inflammatory cells and psoriasis of pemphigus patients showed that HSP70 is involved in the pemphigus.
