Reserch on the Tlyroid Function Reference Range of Different Pregnancy Period of Normal Pregnant Women

Jie Zhang; Ying Kou; Li MA; Shaohua Liu; Xuemin Zhang; Zhengfu Chen

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Reserch on the Tlyroid Function Reference Range of Different Pregnancy Period of Normal Pregnant Women

VernacularTitle:正常孕妇不同孕期甲状腺功能参考范围的分析研究
Author: Jie ZHANG ; Ying KOU ; Li MA ; Shaohua LIU ; Xuemin ZHANG ; Zhengfu CHEN
Keywords: pregnancy; thyroid hormone; the normal reference range
From: Journal of Modern Laboratory Medicine 2017;32(3):144-145,148
CountryChina
Language:Chinese
Abstract: Objective To establish the reference range of thyroid function from the normal pregnant women in different pregnant period in Hanzhong region.Methods According to the NACB inclusion criteria,collected local resident pregnant women 4 031 cases,from July 2012 to December 2015.With the combination of random sampling,stratified sampling and cluster sampling,thyroid hormone levels were measured by a fully automated chemiluminescence analyzer and its accompanying reagents.All patients were divided into three groups:998 cases in early pregnancy (T1),1 543 cases in mid-pregnancy (T2),1 490 cases in late pregnancy (T3),and 105 cases of non-pregnant women in childbearing age (T0) were selected as control group.Results The levels of thyroid hormones were different among three periods of pregnant women.TSH were 0.25～5.32,0.42～6.26 and 0.61～7.68 mIU/L respectively in the early,middle and late stages.FT3 were 3.54～6.04,3.57～5.94 and 2.93～5.40 pmol/L,respectively.FT4 was 7.11～16.88,6.78～16.94 and 6.03～16.87 pmol/L.Thyroid hormone levels in pregnant women compared with non-pregnant women,there were significant differences (TSH:x2=233.183,P＜0.05,FT4:x2 =388.12,P＜0.05 and FT3:x2 =558.795,P＜0.05).TSH were lower in early pregnant women comparing to non-pregnancy women,and higher in middle-late pregnant women.The change of FT3 and FT4 were consistent,and reduced with the extension of pregnancy comparing to non-pregnancy women.Conclusion The level of thyroid function in pregnant women were different from non-pregnant women.and the normal reference range of local pregnant specific thyroid hormone should be established.