Updates on the Pathways of Toll-Like Receptors Mediated by HMGB1
10.3969/j.issn.1671-7414.2017.03.045
- VernacularTitle:高迁移率蛋白B1介导Toll样受体信号通路的研究进展
- Author:
Fangping WANG
;
Pingan ZHANG
;
Xiaoyan YANG
- Keywords:
high mobility group box 1 protein;
toll-like receptor;
signaling pathway
- From:
Journal of Modern Laboratory Medicine
2017;32(3):162-164
- CountryChina
- Language:Chinese
-
Abstract:
High mobility group box 1 protein,a kind of damage-associated molecular patterns,is a group of nonhistone DNA-binding protein in the nuclear.It not only involves in DNA replication,recombination,repair,regulation of gene transcription,but also induces activation of innate immunity and T cell generation and activates the adaptive immune response through Toll-like receptor.It is also more closely related to autoimmune diseases,inflammatory diseases,tumors and so on.Currently there are many researches on the role of TLR-mediated HMGB1 signaling pathway in diseases,which is involved in a variety of pathological processes and has a broad clinical outlook.
