Synthesis and antiproliferative activities of 5H-benzo[b] carbazole-6,11-diones
10.11665/j.issn.1000-5048.20170205
- VernacularTitle:5H-苯并[b]咔唑类化合物的合成与肿瘤细胞增殖抑制活性
- Author:
Sufen CAO
;
Qin XIE
;
Yi CHEN
;
Wenhu DUAN
- Keywords:
5H-benzo[b] carbazole-6,11-dione;
synthesis;
antiproliferative activity
- From:
Journal of China Pharmaceutical University
2017;48(2):157-166
- CountryChina
- Language:Chinese
-
Abstract:
A series of 5H-benzo[b] carbazole derivatives were synthesized to find new TopⅡ inhibitors.The substitution pattern at C-9 was discussed.All 16 compounds were tested for their antiproliferative activities against 4 tumor cell lines (SMMC-7721,S1,HCT116,and HeLa) by sulforhodamine B assay.Four compounds were found to inhibit the proliferation of all tested cell lines.And compound 10e displayed the best antiproliferative activity against all 4 tested cell lines with IC50 values of 5.06,4.50,5.29,and 6.32 μmol/L,respectively.
