Advances in antidiabetic small molecule ABHD6 inhibitors
10.11665/j.issn.1000-5048.20170201
- VernacularTitle:抗糖尿病小分子ABHD6抑制剂的研究进展
- Author:
Lianghui SI
;
Hui MA
;
Jinpei ZHOU
;
Huibin ZHANG
- Keywords:
glucose and lipid metabolism;
α/β hydrolase domain-6;
ABHD6 inhibitors;
antidiabetic drugs;
advances
- From:
Journal of China Pharmaceutical University
2017;48(2):125-134
- CountryChina
- Language:Chinese
-
Abstract:
Type 2 diabetes,a glucose and lipid metabolism disorder accompanied by chronic multiple organ damage,has become a huge threat to human health,α/β hydrolase domain-6 (ABHD6) regulates the insulin release negatively by hydrolyzing monoacylglycerol.Small molecule ABHD6 inhibitors have been proven to lower bloodglucose and regulates energy homeostasis,which is a potential candidate for the treatment of type 2 diabetes.This paper introduced the ABHD6 signaling pathway and its mechanism,then reviewed the progress of small molecule ABHD6 inhibitors with different structures in recent years,and analyzed the structure activity relationship.
