Adverse effects, drug interactions, and safety of direct-acting antiviral agents in treatment of hepatitis C
10.3969/j.issn.1001-5256.2017.06.010
- VernacularTitle:直接抗病毒药物治疗丙型肝炎的毒副作用、物相互作用及安全性
- Author:
Xitai ZHAO
;
Qinghe NIE
- Keywords:
hepatitis C;
antiviral agents;
drug interactions
- From:
Journal of Clinical Hepatology
2017;33(6):1067-1074
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,direct-acting antiviral agents (DAAs) have achieved great success in the treatment of hepatitis C and have replaced interferon/ribavirin.However,since DAAs were launched not long ago,there lacks sufficient knowledge of their toxic and side effects,interactions with other drugs,and safety in patients complicated by other serious chronic diseases.The results of many large-scale clinical trials show that DAAs have good safety in different populations and serious toxic and side effects are rare,but drug interactions need to be taken seriously.The addition of ribavirin in DAA regimen or prolongation of DAA treatment does not increase patients' benefits and may cause more adverse events.Moreover,at the same time of DAA treatment,liver injury caused by HCV cannot be neglected,and continuous treatment should be given.
