Research advances in the pathogenesis of multiple organ dysfunction syndrome in patients with liver cirrhosis and related treatment regimens
10.3969/j.issn.1001-5256.2017.06.032
- VernacularTitle:肝硬化并发多器官功能障碍的发病机制与治疗方案
- Author:
Tianyi GU
;
Lungen LU
- Keywords:
liver cirrhosis;
hypertension,portal;
multiple organ failure;
review
- From:
Journal of Clinical Hepatology
2017;33(6):1165-1168
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have shown that complications of cirrhotic portal hypertension often involve multiple organs,which is called multiple organ dysfunction syndrome by some scholars.When muhiple organ failure occurs,there is a significant increase in patients'short-term death rate,and death rate is associated with the number of organs involved.This article briefly describes the physiopothologic mechanisms of portal hypertension and visceral vasodilation and summarizes the pathological changes of vital organs including the heart,lung,kidney,brain,and liver and related pathogenesis.At present,liver transplantation remains the most effective therapy,but it still has some shortcomings.It is pointed out that further studies are needed to investigate the mechanisms of action of each link in disease development,and more targets are needed in the future to prevent and treat multiple organ dysfunction syndrome in patients with liver cirrhosis.
