Research advances in hepatitis C virus-related renal injury and its treatment
10.3969/j.issn.1001-5256.2017.06.030
- VernacularTitle:HCV相关肾损伤及其治疗的研究进展
- Author:
Shuyuan LU
;
Huiying RAO
- Keywords:
hepacivirus;
kidney diseases;
cryoglobulinemia;
antiviral agents;
review
- From:
Journal of Clinical Hepatology
2017;33(6):1156-1160
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis C virus (HCV) is a blood-borne virus transmitted through contact with blood and blood products,and it is a major cause of liver cirrhosis and hepatocellular carcinoma.Many epidemiological studies have confirmed the association between HCV infection and renal disease.Membranoproliferative glomerulonephritis associated with mixed cryoglobulinemia is the most common type of HCV-related renal disease manifesting as nephropathy or nephritic syndrome,proteinuria,hematuria,and reduced glomerular filtration rate.The treatment of HCV-related renal disease includes antiviral therapy,B cell clearance,and non-specific immunosuppressive therapy.At the same time,the launch of rnew antiviral drugs has brought hope to the patients who cannot tolerate conventional regimens.This article reviews the research advances in epidemiology,clinical manifestations,pathogenesis,and treatment of HCV-related renal injury.
