Research advances in the pathogenesis of bile acid-related non-alcoholic fatty liver disease and related pharmacotherapy
10.3969/j.issn.1001-5256.2017.06.034
- VernacularTitle:胆汁酸相关非酒精性脂肪性肝病发病机制及其药物治疗的研究进展
- Author:
Min ZHANG
;
Mingxing HUANG
;
Liejun GUO
- Keywords:
fatty liver;
cholic acids;
receptors,G-protein-coupled;
review
- From:
Journal of Clinical Hepatology
2017;33(6):1173-1178
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic fatty liver disease (NAFLD) has become a new health issue in the world due co its increasing incidence rate,and in particular,nonalcoholic steatohepatitis is progressive and has poor prognosis.Therefore,there is an argent need to search for the methods for the prevention of disease progression and treatment.Bile acid,as an important metabolite and signal molecule,can adjust the metabolism of lipids and carbohydrates and energy balance inside and outside the liver.Bile acid interacts with is receptors,such as the farnesoid X receptor and Takeda G-protein coupled receptor 5,bile acid transporter,and gut microbiota and is involved in the pathogenesis of NAFLD and nonalcoholic steatohepatitis at different levels.This article summarizes the research advances in the pathogenesis of bile acid-related NAFLD and related pharmacotherapy.
