Changes and Significance of Serum Levels of Inflammatory Cytokines and Immunoglobulin in Children with Hand-foot-and-mouth Disease Infected by EV71

VernacularTitle:EV71感染手足口病患儿血清炎性细胞因子及免疫球蛋白水平的变化及意义
Author: Xuzhen LU ; Keyin WANG ; Danfeng SUN
Keywords: Enterovirus 71; Hand-foot-and-mouth disease; Cytokines; Immunoglobulin
From: Journal of Medical Research 2017;46(6):114-116
CountryChina
Language:Chinese
Abstract: Objective Observe the changes of cytokine and immunoglobulin in children with Hand-foot-and-mouth disease (HFMD) infected by Enterovirus 71 (EV71),to explore the significance of inflammation and immunological mechanisms.Methods A total of 65 cases of children with HFMD by EV71 were taken as the observation group,and 65 cases of healthy children were as the control group in June 2015-August 2016.The serum levels of IL-6,IL-8,TNF-α were detected by enzyme-linked immunosorbent assay (ELISA),and the levels of IgA,IgG,IgM were detected by immune scattering turbidimetric.Results Compared with control group,the levels of IL-6,IL-8 and TNF-α in observation group were significantly increased (t=7.94,6.87,9.56,P ＜ 0.01),the levels of IgA,IgG and IgM also increased,differences were statistically significant (t =6.71,7.96,8.39,P ＜ 0.01).Conclusion The inflammatory cytokines and immune imbalance in the development of HFMD play an important role,observe the dynamic changes of IL-6,IL-8,TNF-α,IgA,IgG and IgM levels has certain clinical application value in preventing and judging the state of HFMD.