Intra-arterial Thrombolytic Therapy in Acute Ischemic Stroke a Preliminary Study.
- Author:
Byung In LEE
1
;
Byung Chul LEE
;
Jin Soo KIM
;
Dong Ik KIM
;
Tae Sub CHUNG
;
Jung Ho SUH
Author Information
1. Department of Neurology, Yonsei University College of Medicine, Korea.
- Publication Type:Original Article
- MeSH:
Cerebral Arteries;
Humans;
Pilot Projects;
Stroke*;
Thrombolytic Therapy*;
Tomography, X-Ray Computed;
Urokinase-Type Plasminogen Activator
- From:Journal of the Korean Neurological Association
1990;8(1):1-13
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We conducted a pilot study to evaluate the possibility that the intra-arterial thrombolybolytic therapy might lead to recanalization of the acutely occluded cerebral arteries and subsequent clinical improvement in patients with acute ischemic stroke. Mean time from the onset of symptoms to the start of treatment and mean dosage of thrombolytic agent, Urokinase, were 6.4 hours and 120.3 X 10(4) units respectively. Seven of 12 cases with acute ischemic stroke demonstrated successful recanalization; 5 cases achieved complete recanalization; 2 cases partial recanalization, and remaining 5 cases did not show any evidence of recanalization. Neurological evaluation at 1 week and 3 months after the onset of symptoms suggested better outcome in a cases with recanalization. Repeat CT scan at 24 hours and 1 week after the procedure demonstrated evidence of hemorrhagic transformation in the infarcted territories in 5 cases(all in recanalized group), but clinical deteriorations were observed in only 2 case. Though statistical analysis could not be done because of the limited number of cases, these results suggest that the intra-arterial thrombolytic therapy had a role in the management of acute major carebral ischemic stroke.
