Clinical research of Docetaxel combined with capecitabine or Gimeracil and Oteracil porassium capsules for elderly patients with advanced gastric cancer
10.3760/cma.j.issn.1008-6315.2017.06.011
- VernacularTitle:多西他赛联合卡培他滨或替吉奥治疗老年进展期胃癌的效果观察
- Author:
Sha LIU
- Keywords:
Docetaxel;
Capecitabine;
Gimeracil and Oteracil Porassium Capsules;
Gastric cancer
- From:
Clinical Medicine of China
2017;33(6):519-523
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe effect and toxicity reaction using the treatment of Docetaxel combined with Gimeracil and Oteracil porassium capsules or capecitabine on elderly patients with advanced gastric cancer.Methods Sventy-eight cases elderly patients with advanced gastric cancer were divided into the combination group (n =40) and the monotherapy group (n =38) randomly by the random number table from February 2010 to December 2012.The patients on the monotherapy group were treated with capecitabine or oral Gimeracil and Oteracil porassium capsules,while the patients on the combination group were treated with Docetaxel in combination of capecitabine or Gimeracil and Oteracil porassium capsules.All therapy were repeated each 3 weeks,and 2 cycles chemotherapy were done at least;meanwhile effect and toxicity reaction were evaluated.At last,time to progress(TTP),median survival time(MST),1-year survival rate and 2-year survival rate were evaluated after completion of follow-up.Results On one other,response rate of the combination group and the monotherapy group were 95％ (38/40) and 79.0％ (30/38),and patients were 38 and 30,respectively;and response rate of the combination group was higher than the monotherapy group(x2 =4.4928;P＜0.05).TTP were 7.9 and 7.6 months on the combination group and the monotherapy group,and the MST were 13.1 months and 12.6 months respectively.The 1-year survival rate were 32.5％,28.95％,and 2-year survival 15.0％,5.27％,similarly,there was no remarkable significance on survival rate(x2=0.12,2.01,P＞0.05).On the other hand,the combination group exhibited more remarkable significance of toxicity reaction than the monotherapy group(P＜0.05),such as hepatotoxicity,baldness,hepatic injury.Conclusion Effect of the combination group was superior to the monotherapy group on elderly patients with advanced gastric cancer.However,there is no longer survival time and more toxicity reaction on the combination group.
