Research development of bone morphogenetic protein-4 in the malignant tumor

VernacularTitle:骨形态发生蛋白4在恶性肿瘤中的作用机制研究进展
Author: Wenjing CAO ; Baogang LIU
Keywords: Bone morphogenetic protein-4; Bone morphogenetic proteins; Malignant tumors; Transfer
From: Clinical Medicine of China 2017;33(6):543-546
CountryChina
Language:Chinese
Abstract: Bone morphogenetic protein-4(BMP4) is one of BMPs member,it not only can play an important role in cell proliferation and invasion,but also play an important role in cell differentiation,apoptosis and angiogenesis.A study showed BMP4 in malignant tumor can inhibit the growth of tumor cells,and also can induce tumor cell invasion,metastasis and epithelial mesenchymal transformation,and SMAD is the classic signaling pathways.BMP4 is expected to become a potential therapeutic targets and in evaluating the prognosis,immune therapy in malignant tumor.In this paper,the structure and function of BMP4 and its mechanism in tumor were reviewed.