Research development of bone morphogenetic protein-4 in the malignant tumor
10.3760/cma.j.issn.1008-6315.2017.06.017
- VernacularTitle:骨形态发生蛋白4在恶性肿瘤中的作用机制研究进展
- Author:
Wenjing CAO
;
Baogang LIU
- Keywords:
Bone morphogenetic protein-4;
Bone morphogenetic proteins;
Malignant tumors;
Transfer
- From:
Clinical Medicine of China
2017;33(6):543-546
- CountryChina
- Language:Chinese
-
Abstract:
Bone morphogenetic protein-4(BMP4) is one of BMPs member,it not only can play an important role in cell proliferation and invasion,but also play an important role in cell differentiation,apoptosis and angiogenesis.A study showed BMP4 in malignant tumor can inhibit the growth of tumor cells,and also can induce tumor cell invasion,metastasis and epithelial mesenchymal transformation,and SMAD is the classic signaling pathways.BMP4 is expected to become a potential therapeutic targets and in evaluating the prognosis,immune therapy in malignant tumor.In this paper,the structure and function of BMP4 and its mechanism in tumor were reviewed.