Research progress of RNF180 value to the diagnosis of gastric cancer
10.3760/cma.j.issn.1008-6315.2017.06.023
- VernacularTitle:RNF180对胃癌诊断价值的研究进展
- Author:
Lei WEN
;
Yichao FENG
;
Jing QIN
;
Xia DU
;
Wen HAN
- Keywords:
RNF180;
Methylation;
Gastric cancer;
Prognosis;
Lymph node metastases
- From:
Clinical Medicine of China
2017;33(6):565-568
- CountryChina
- Language:Chinese
-
Abstract:
RNF180 is a novel membrane-bound E3 ubiquitin ligase that participates in cell development,proliferation and apoptosis.It is a tumor suppressor gene that inhibits cell proliferation and induces apoptosis and may inhibit gastric cancer cell lymph node metastasis.The study found that RNF180 gene methylation and gastric cancer is closely related to the occurrence and development.Therefore,RNF180 gene methylation is expected as a tumor marker of gastric cancer for early diagnosis and prognosis of gastric cancer.In this paper,RNF180 on the diagnosis of gastric cancer research progress made a review.
