Hedgehog signaling pathway and cartilage damage
10.3760/cma.j.issn.2095-4255.2017.08.019
- VernacularTitle:Hedgehog信号通路与软骨损伤
- Author:
Pan YAN
- Keywords:
Hedgehog signaling pathway;
Regulatory mechanism;
Cartilage damage
- From:
Chinese Journal of Endemiology
2017;36(8):621-624
- CountryChina
- Language:Chinese
-
Abstract:
Hedgehog signaling pathway plays an key role in the process of endochondral bone formation, regulating the proliferation and differentiation of chondrocytes in epiphyseal growth plate. In recent years, it has been found that abnormal expression of Hedgehog signaling pathway-related molecules is involved in a variety of osteoarthropathy. Therefore, studying the relationship between Hedgehog signaling pathway and cartilage damage is of great significance to elucidate the molecular mechanism of osteoarthropathy. In this paper, we focus on the research progress of Hedgehog signaling pathway in chondrocyte proliferation, differentiation, apoptosis and cartilage matrix metabolism, which may provide new insights into mechanism and prevention of osteoarthropathy.
