Effect of granulocyte-macrophage colony-stimulating factor gargle in control of the oral mucositis after allogeneic hematopoietic stem cell transplantation
10.3760/cma.j.issn.1672-7088.2017.22.002
- VernacularTitle:粒-巨噬细胞集落刺激因子漱口液治疗异基因造血干细胞移植相关的口腔黏膜炎的效果评价
- Author:
Wei HU
;
Xia YAN
;
Ting WANG
;
Xiaodong XU
;
Shuang DONG
;
Ce SHI
;
Shujia LIU
- Keywords:
Granulocyte-macrophage colony-stimulating factor;
Oral mucositis;
Allogeneic hematopoietic stem cell transplantation
- From:
Chinese Journal of Practical Nursing
2017;33(22):1687-1690
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the efficacy of granulocyte-macrophage colony-stimulating factor (GM-CSF) gargle in patients who had oral mucositis after allogeneic hematopoietic stem cell transplantation. Methods A total of 134 patients were enrolled in this study from 2014 to 2015. They were randomly divided into two groups:the experimental group (n=65) and the control group (n=69). Both groups received preventive measures for oral mucositis. But once oral mucositis occurred, the control group continued with the routine nursing measure, while the experimental group added GM-CSF gargle based on previous routine nursing measure. The effective rate and healing time were compared between two groups. Results The effective rate of the experimental group (81.54%, 53/65) was significantly higher than that of the control group (24.64%,17/69) (χ2=43.434, P=0.000). The median healing time in the experimental group was 4.5 days, shorter than 9.0 days in the control group (Z=-5.379, P< 0.01). Conclusions GM-CSF gargle can control the oral mucositis after allogeneic hematopoietic stem cell transplantation.
