Apparent diffusion coefficient histogram analysis: differentiation of clear cell renal cell carcinoma from non-clear cell renal cell carcinoma with r-field of view diffusion weighted imaging
10.3760/cma.j.issn.1005?1201.2017.09.007
- VernacularTitle:小视野扩散加权成像表观扩散系数直方图鉴别透明细胞与非透明细胞肾癌的价值
- Author:
Haojie LI
;
Lili LIANG
;
Anqin LI
;
Yonghong HAO
;
Yao HU
;
Daoyu HU
;
Zhen LI
- Keywords:
Kidney neoplasms;
Magnetic resonance imaging;
Histogram
- From:
Chinese Journal of Radiology
2017;51(9):665-668
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the utility of ADC histogram analysisin differentiation of clear cell renal cell carcinoma(ccRCC)and non-clear cell renal cell carcinoma(non-ccRCC)with r-Fov DWI. Methods Sixty-six renal tumors(46 patients with 47 ccRCCs and 18 patients with 19 non-ccRCCs)in 64 patients, who underwent preoperative routine renal MRI sequences and r-FOV DWI, were retrospectively evaluated. The whole-lesion ADC values derived from histogram anlysis(including ADC mean, ADC median, ADC_5th, ADC_25th, ADC_75th, ADC_95th, skew and kurtosis)were measured for each patient. All parameters between ccRCC and non-ccRCC were compared by using the Student's t test or Mann-Whitney U test. ROC analysis was used to assess the diagnostic performance of ADC histogram in distinguishing the two groups. Results The postive skewness of ADC histograms were mostly seen in the non-ccRCC group, while the negtative skewness were present in the majority of ccRCCs. The skewness was significantly higher in non-ccRCCs than those of ccRCCs(P<0.05). Mean ADC, median ADC, 5th percentile ADC, 25th percentile ADC, 75th percentile ADC and 95th percentile ADC(all P<0.05)were significantly lower in non-ccRCC . There was no significant difference of Kurtosis between two groups(P>0.05). 75th percentile ADC achieved the highest AUC(0.987)in differentiating ccRCC and non-ccRCC, whena cutoff value was 1.81× 10-3 mm2/s. The sensitivity and specificity were 100.0％and 94.7％. Conclusion ADC histograms of r-FOV DWI may be helpful to differentiate ccRCC from non-ccRCC, and the diagnostic accuracy of 75th percentile ADC is highest.
