Significance of neuromedin U expression in lymph node metastasis of laryngocarcinoma

VernacularTitle:神经调节肽U在喉癌淋巴结转移中的表达及意义
Author: Qichuan JIANG ; Dong CHEN ; Yanan XU ; Jian KANG ; Jianguo CHEN
Keywords: Laryngeal Neoplasms; Lymph Nodes; neuromedin U
From: Chinese Archives of Otolaryngology-Head and Neck Surgery 2017;24(7):340-342
CountryChina
Language:Chinese
Abstract: OBJECTIVE To evaluate the effect of neuromedin U(NMU) in lymph node metastasis of laryngocarcinoma and provide a new biomarker of metastasis. METHODS Samples of 120 cases of laryngocarcinoma were collected from the Otolaryngology Department of the First Affiliated Hospital of Jinzhou Medical University from 2013 to 2015. Patients were divided into two groups: metastasis group and non-metastasis group. Immunohistochemistry was performed to analyze the NMU expression in primary tumor and lymph node. An independent tissue microassay was used to analyze the relationship between NMU expression and T, N stages. RESULTS Expression of NMU in metastasis group was higher than that in non-metastasis group, NMU was positively correlated with N stages, but not with T stages. CONCLUSION The expression of NMU is higher in metastasis tissue of laryngocarcinoma, It could be used as a biomarker of lymph node metastasis of laryngocarcinoma.