Study on the peripheral blood T lymphocyte subsets and natural killer cell in children with asthmatic pneumonia
10.3969/j.issn.1673-4130.2017.17.012
- VernacularTitle:喘息性肺炎患儿全血中T淋巴细胞亚群和自然杀伤细胞的表达研究
- Author:
Yonghong HUANG
;
Ying KANG
;
Dengke HAN
;
Qiong CHEN
- Keywords:
asthmatic;
pneumonia;
application value;
receiver operating characteristic curve
- From:
International Journal of Laboratory Medicine
2017;38(17):2365-2366,2370
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and significance of peripheral blood T lymphocyte subgroups and natural killer cell in children with asthmatic pneumonia.Methods From 2013 to 2016,asthmatic children with pneumonia were erolled in the study as asthmatic pneumonia group(36 cases) and 36 cases medical health children as control group at the same time in Zhongshan City people′s hospital.Flow cytometry was used to test analysis of two groups of T lymphocyte subsets and natural killer cell in serum and the expression of CD28,CD56,using ROC curve analysis results.Results Asthmatic pneumonia group compared with control group,the difference of CD3+ and CD3+CD8+,CD28+,CD8+CD28+,CD8+CD28-,CD3-CD16+CD56+ and CD3+CD16+CD56+,CD3+CD4+/CD3+ CD8+ was statistically significant(P<0.05).According to the results of flow parameters have higher sensitivity by the ROC curve statistics.Conclusion Asthmatic pneumonia children have immune dysfunction,immune function changes associate with asthmatic,which is of great clinical significance to carry out immune function detection for children with asthmatic pneumonia.
