Values of serum levels of PCT and ET in predicting postoperative pulmonary bacterial infection in patients with abdominal trauma
10.3969/j.issn.1673-4130.2017.17.028
- VernacularTitle:血清PCT和ET水平在预测腹部创伤术后肺部细菌感染中的价值
- Author:
Qingying YUN
- Keywords:
abdominal trauma;
procalcitonin;
endotoxin;
pulmonary infection
- From:
International Journal of Laboratory Medicine
2017;38(17):2413-2415,2418
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the values of serum levels of PCT and ET in predicting postoperative pulmonary bacterial infection in patients with abdominal trauma.Methods Totally 115 cases of postoperative pulmonary bacterial infection in patients with abdominal trauma were divided into bacterial infection group(n=83) and non-bacterial infection group(n=32).According to the results of Gram stain,patients in the bacterial infection group were divided into G-infection group(n=49) and G+ infection group(n=34).According to the CURB-65 score,patients in the bacterial infection group were divided into mild group(n=49),moderate group(n=21) and severe group(n=13).The serum levels of PCT and ET were detected.The values of serum levels of PCT and ET in predicting bacterial infection and pathogen type were analyzed by using the receiver operating characteristic curve(ROC curve).Results The serum levels of PCT and ET in bacterial infection group were higher than the non-bacterial infection group,the differences were statistically significant(P<0.05).The serum levels of PCT and ET in G-infection group and G+ infection group were higher than the non-bacterial infection group,and G-infection group were higher than the G+ infection group,the differences were statistically significant(P<0.05).The serum levels of PCT and ET in moderate and severe group were higher than the mild group,the differences were statistically significant(P<0.05).In G-infection group,the serum levels of PCT and ET in moderate and severe group were higher than the mild group,the differences were statistically significant(P<0.05).ROC curve showed that the area under the curve for serum levels of PCT was 0.988(95％CI:0.973-1.000),when the serum levels of PCT=0.26 ng/mL,the sensitivity was 95.2％ and the specificity was 96.9％,and for serum levels of ET,the area under the curve was 0.905(95％CI:0.850-0.960),when the serum levels of ET=0.05 EU/mL,the sensitivity was 84.3％ and the specificity was 96.8％.The area under the curve for serum levels of PCT in predicting the pathogen type was 0.959(95％CI:0.923-0.995),when the cut-off value of PCT was 0.63 ng/mL to distinguish between G+ bacteria and G-bacteria,the sensitivity was 98.0％ and the specificity was 82.4％,for serum levels of ET,the under the curve was 0.885(95％CI:0.801-0.970),when the cut-off value of ET was 0.13 EU/mL,the sensitivity was 83.7％ and the specificity was 97.1％.Conclusion The serum levels of PCT and ET in postoperative pulmonary bacterial infection in patients with abdominal trauma are significantly increased,and are related with the severity of the disease.They could be uses as indexes to identify the type of pathogenic bacteria.
