Progress on autophagy induced by endoplasmic reticulum stress in tumor research

VernacularTitle:内质网应激诱导的自噬在肿瘤中的研究进展
Author: Lijuan HUANG ; Haifeng WANG
Keywords: Autophagy; Endoplasmic reticulum stress; Tumor
From: Journal of Medical Postgraduates 2017;30(9):973-976
CountryChina
Language:Chinese
Abstract: Endoplasmic reticulum stress will be happened when cells suffer from severe adverse stimulation.Endoplasmic reticulum stress can induce autophagy.Autophagy and endoplasmic reticulum stress can protect cell for survival, however, they can trigger cell death.In tumor cells, the mutual regulation of autophagy and endoplasmic reticulum stress leads to the imbalance between cell survival and death, which is one of the important factors in determining the efficacy of some antitumor drugs.This paper reviews the progress on autophagy induced by endoplasmic reticulum stress in tumor and the effect of autophagic inhibitors on chemosensitivity.