Research progress on effect of microRNAs in the pathogenesis of nonalcoholic fatty liver disease
10.16571/j.cnki.1008-8199.2017.09.017
- VernacularTitle:MicroRNAs在非酒精性脂肪性肝病中作用的研究进展
- Author:
Jing FANG
;
Nanyuan FANG
- Keywords:
MicroRNAs;
Nonalcoholic fatty liver disease;
Mechanism
- From:
Journal of Medical Postgraduates
2017;30(9):977-981
- CountryChina
- Language:Chinese
-
Abstract:
Post-transcriptional regulation of gene expression is an important contributor to disease pathogenesis.MicroRNAs (miRNAs) are endogenous, conserved, single-stranded non-coding small RNA with 18-25 nucleotides in length, which regulate gene expression post-transcriptionally.Several studies found that miRNAs could affect the development of nonalcoholic fatty liver disease through multiple ways.This article reviews the roles of miRNAs in the development of nonalcoholic fatty liver disease by regulating lipid metabolism, insulin resistance, oxidative stress, inflammatory, intestinal mucosal barrier, cell apoptosis and so on.
