Research progress of long non-coding RNA related to breast cancer
10.19401/j.cnki.1007-3639.2017.08.011
- VernacularTitle:乳腺癌相关长链非编码RNA的研究进展
- Author:
Lei LIU
- Keywords:
Long non-coding RNA;
Breast cancer;
Tumorigenesis;
Progression;
Molecular marker
- From:China Oncology
2017;27(8):668-674
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNA (lncRNA) is a group of functional RNA molecules, which is more than 200 nu-cleotides in length, lacks ability of encoding protein and participates in all aspects of gene regulation. The current studies have indicated that some lncRNAs take part in regulating the process of breast cancer tumorigenesis and progression. This article reviewed the abnormal expression of lncRNA in breast cancer, its relationship to breast cancer growth, apoptosis, invasion and metastasis, and its function in early diagnosis, drug resistance and prognosis of breast cancer. This review was expected to offer an insight into a new target for the prediction, diagnosis and individual treatment of breast cancer.
