The application of Oncotype DX 21-gene assay in early-stage ER positive breast cancer
10.19401/j.cnki.1007-3639.2017.08.012
- VernacularTitle:Oncotype DX 21基因检测在ER阳性早期乳腺癌中的应用
- Author:
Ying ZHANG
- Keywords:
Breast cancer;
Oncotype DX;
21-gene assay;
Prognosis;
Chemotherapy
- From:China Oncology
2017;27(8):675-680
- CountryChina
- Language:Chinese
-
Abstract:
Several multi-gene assays have been developed to predict the risk of recurrence in patients with early-stage, estrogen receptor (ER) positive breast cancer. Among them, Oncotype DX 21-gene assay is widely applied among node-negative patients because of its unique prediction of therapeutic benefit. Although many retrospective stud-ies have proved its prognostic and predictive value in node-positive population, evidence from large prospective clinical trials remains insufficient. When combined with clinicopathological variables, the assay has been shown to impact adjuvant treatment decision making in a cost-effective manner. This article reviewed the available clinical evidence for the prognostic and predictive value, unique advantages, the effect on treatment decision making, cost-effectiveness and contradictories of 21-gene assay in early-stage luminal breast cancer patients.
