The level of glycogen phosphorylase isoenzyme BB and ischemia modified albumin in newborn with asphyxia and myocardial injury and its clinical significance
10.3969/j.issn.1673-4130.2017.17.003
- VernacularTitle:糖原磷酸化酶同工酶脑型和缺血修饰蛋白在新生儿窒息合并心肌损伤中的变化及临床意义
- Author:
Bin TIAN
;
Lanfeng LIU
;
Huzhong DENG
;
Fenglian LI
;
Haiyan LIU
- Keywords:
neonatal asphyxia;
myocardial injury;
glycogen phosphorylase isoenzyme BB;
ischemia modified protein
- From:
International Journal of Laboratory Medicine
2017;38(17):2342-2343,2346
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of early biomarkers in neonatal asphyxia diagnosis with myocardial damage by detection of ischemia modified albumin in neonatal serum(IMA) and glycogen phosphorylase isoenzyme BB(GPBB) for screening sensitive markers with direct myocardial injury.Methods 166 neonates were selected in our hospital as the research object,in which 136 cases with myocardial injury dividend into the experimental group and 30 cases into the control group.The experimental group were divided into mild group and severe group according to the degree of asphyxia.All the children were tested for GPBB and IMA 1 h after admission.Results The levels of GPBB in neonatal asphyxia myocardial injury group and severe asphyxia group were significantly higher than those in the control group,the difference was statistically significant(P<0.05).The sensitivity of GPBB in diagnosis of asphyxia was higher than that of IMA,the difference was statistically significant(P<0.05).Conclusion The degree of asphyxia is closely related to serum IMA,GPBB level in neonatal asphyxia complicated with myocardial injury.The sensitivity and specificity of GPBB in diagnosis asphyxia is better than IMA in children complicated with myocardial damage.
