Expression of Ang-2 and HSP90α in serum of patients with non-small cell lung cancer and its correlation with TNM staging
10.3969/j.issn.1673-4130.2017.17.004
- VernacularTitle:Ang-2、HSP90α在老年非小细胞肺癌患者血清中的表达及与TNM分期的相关性研究
- Author:
Abudoureyimu ABUDOUSHALAMU
;
Jing YANG
;
Saiding AILI
- Keywords:
Ang-2;
HSP90α;
non-small cell lung cancer;
TNM staging
- From:
International Journal of Laboratory Medicine
2017;38(17):2344-2346
- CountryChina
- Language:Chinese
-
Abstract:
Objective The expression of Ang-2 and HSP90α in serum of patients with non-small cell lung cancer and their correlation with TNM staging were analyzed.Methods From January 2015 to June 2016,40 patients with elderly non-small cell lung cancer and 40 healthy persons were selected as the study subjects.The serum levels of Ang-2 and HSP90 alpha in the subjects were examined and their correlation with the TNM stage of the patients was analyzed.Results Observation of Ang-2 and HSP90α levels in the serum of the patients group were significantly higher than the control group,and the difference was statistical significance(P<0.05);Serum Ang-2 and HSP90α levels TNM Ⅰ-Ⅱ patients were significantly lower than that of stage Ⅲ and Ⅳ,the difference was statistical significance(P<0.05);Serum Ang-2 and HSP90α levels in TNM Ⅲ patients was significantly lower than those in stage Ⅲ and Ⅳ,the difference was statistical significance(P<0.05);TNM staging was positively correlated with the levels of HSP90α in serum,and statistical significance(r=0.425,P<0.05),TNM stage had a remarkably positive correlation with the level of Ang in serum(r=0.525,P<0.05).Conclusion The levels of Ang-2 and HSP90α were significantly higher in the serum of elderly patients with non-small cell lung cancer,and the expression level was positively correlated with TNM stage.
