Expression of CRP and IL-6 in serum of patients with AD and its value analysis
10.3969/j.issn.1673-4130.2017.17.033
- VernacularTitle:CRP、IL-6在AD患者血清中的表达情况及其价值分析
- Author:
Qun LIU
;
Qi ZHANG
- Keywords:
Alzheimer′s disease;
C-reactive protein;
interleukin;
cognitive
- From:
International Journal of Laboratory Medicine
2017;38(17):2426-2428
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Alzheimer′s disease(AD) patients with serum CRP,IL-6,and analyze its clinical significance.Methods The clinical data of 85 patients with AD (AD group)treated in our hospital from March 2015 to June 2016 were retrospectively analyzed,and the data of 85 healthy adults were selected as control group.The differences of serum CRP,IL-6 levels,the mini mental state rating scale(MMSE) and the daily living ability rating scale(BI) score of the two groups were observed,and the correlation between CRP,IL-6 and MMSE and BI scores in patients with AD was analyzed.Results The levels of CRP and IL-6 in the AD group were significantly higher than those in the control group,the difference was statistically significant(P<0.05);The scores of directional function,instantaneous memory,attention and computational power were significantly lower in the AD group than those in the control group,the difference was statistically significant(P<0.05);The daily living ability scores of patients in AD group were lower than those in the control group,such as eating,bathing and dressing,and the difference was statistically significant(P<0.05);Serum CRP and IL-6 levels in patients with AD were negative correlation with MMSE and BI scores(P<0.05).Conclusion The levels of CRP and IL-6 in serum of patients with AD are high,and are closely related to the patients′ mental symptoms and daily living ability.
