Baseline Predictors of Visual Acuity and Retinal Thickness in Patients with Retinal Vein Occlusion.
10.3346/jkms.2015.30.4.475
- Author:
Sang Jin KIM
1
;
Young Hee YOON
;
Ha Kyoung KIM
;
Hee Seong YOON
;
Se Woong KANG
;
June Gone KIM
;
Kyu Hyung PARK
;
Young Joon JO
;
Dong Hoon LEE
Author Information
1. Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Retinal Vein Occlusion;
Macular Edema;
Vascular Endothelial Growth Factor A;
Visual Acuity;
Tomography, Optical Coherence
- MeSH:
Adult;
Aged;
Female;
Humans;
Male;
Middle Aged;
Retina/*pathology;
Retinal Vein Occlusion/pathology/*physiopathology;
*Visual Acuity
- From:Journal of Korean Medical Science
2015;30(4):475-482
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study investigated the baseline predictors of best corrected visual acuity (BCVA) and central retinal thickness (CRT) at 6 months in patients with treatment-naive branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO). This multicenter, interventional case series included 208 BRVO and 123 CRVO patients with follow-up period of 6 months or more. Outcome measures of BCVA (logMAR) included absolute change from baseline and a gain or loss of > or = 0.3 from baseline. Outcome measures of CRT included absolute change from baseline and a measurement of < or = 250 microm or > or = 400 microm at 6 months. Univariate and multiple regression analyses were done to find baseline predictors. For BRVO, younger age, worse baseline BCVA, and shorter duration of symptom were associated with more gain in BCVA. For CRVO, worse baseline BCVA was associated with more gain in BCVA. For CRT outcomes, higher baseline CRT predicted greater decrease at 6 months in both BRVO and CRVO. Younger age and better baseline BCVA were associated with an increased likelihood of measurement of a < or = 250 microm outcome for BRVO and CRVO, respectively. For CRVO, smoking was associated with greater decrease from baseline and decreased likelihood of measurement of a CRT > or = 400 microm at 6 months. In conclusion, several baseline factors including age, symptom duration, and baseline BCVA and CRT are associated with BCVA and CRT outcomes at 6 months, which may help to predict disease course for RVO patients.
