Correlation of serum cystatin C and N-terminal pro-brain natriuretic peptide with severity of coronary heart disease
10.3760/cma.j.issn.1008-6706.2017.15.002
- VernacularTitle:血清胱抑素C和N端脑钠肽前体水平与冠心病患者冠状动脉病变程度的相关性研究
- Author:
Danyang YING
- Keywords:
serum cystatin C (CysC);
Natriuretic peptide;
brain;
Coronary artery disease
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(15):2246-2249
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of serum cystatin C(CysC) and N-terminal brain natriuretic peptide (NT-proBNP) levels with severity of coronary heart disease.Methods 240 patients with coronary artery disease were selected.According to coronary angiography,they were divided into four groups:52 cases of non-CAD group,coronary single vessel disease group (73 cases),62 cases of double vessel disease,53 cases of triple vessel disease group.The serum CysC,NT-proBNP levels were determined and compared among the four groups.The relationship between CysC,NT-proBNP levels and severity of coronary artery disease was analyzed.Results The CysC,NT-proBNP levels in the single coronary vessel disease group,double vessel disease group and multivessel disease group were higher than non-CHD group,the differences were statistically significant(t=2.019,3.870,7.449,P=0.046,0.000,0.000;t=6.068,15.365,24.851,P=0.000,0.000,0.000);and with the crown pulse lesion count increased,the serum CysC,NT-proBNP levels increased gradually,the differences were statistically significant(t=2.080,3.070,P=0.039,0.000;t=10.953,12.078,P=0.000,0.000).Coronary artery disease severity was positively correlated with CysC,NT-proBNP levels (r1=0.562,r2=0.503).Conclusion The severity of coronary artery disease is closely related to the levels of CysC,NT-proBNP,which has some predictive value for coronary artery disease,patients with high CysC,NT-proBNP levels should be given high priority.
