Effect of hyperbaric oxygen therapy on lupus encephalopathy and its influence on serum CRP and renal function
10.3760/cma.j.issn.1008-6706.2017.15.003
- VernacularTitle:高压氧治疗狼疮性脑病疗效及对血清C反应蛋白及肾功能的影响
- Author:
Xiaoxia LIU
- Keywords:
Lupus erythematosus;
systemic;
Brain injury;
chronic;
Hyperbaric oxygen;
C-reactive protein
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(15):2250-2253
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of hyperbaric oxygen therapy on lupus encephalopathy and its influence on serum CRP and renal function.Methods 100 patients with lupus encephalopathy were selected and they were randomly divided into observation group and control group according to the digital table.The control group was treated with routine therapy.The observation group was given hyperbaric oxygen therapy and routine therapy.The therapeutic effects of two groups were compared and the changes of CRP level and the improvement of renal function before and after treatment were analyzed.Results The total effective rate of the observation group was 96.00%,which was significantly higher than 68.00% of the control group (χ2=13.279,P=0.000).After treatment for 3d,5d,7d,the CRP levels of the observation group were (17.53±1.58)μg/mL,(14.59±1.52)μg/mL,(9.39±1.01)μg/mL,respectively,which were significantly lower than those of the control group[(20.48±1.78)μg/mL,(18.49±1.32)μg/mL,(13.24±1.13)μg/mL],the differences were statistically significant (all P<0.05).After treatment,the blood urea nitrogen (BUN),serum creatinine (SCr) of the observation group were significantly better than those of the control group,the differences were statistically significant (t=12.069,15.203,P=0.000,0.000).Conclusion Hyperbaric oxygen exerts significant effect in treatment of lupus encephalopathy can improve symptoms,promote the recovery of CRP levels,relieve renal function,and has clinical significance.
