Comparison of the anesthesia effects of sevoflurane and propofol in extensive hysterectomy patients and the influence on cognitive function
10.3760/cma.j.issn.1008-6706.2017.15.015
- VernacularTitle:七氟烷与丙泊酚对全子宫切除术患者认知功能的影响及麻醉效果比较
- Author:
Liwen SU
- Keywords:
Hysterectomy;
Sevoflurane;
Propofol;
Anesthesia;
Cognitive function
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(15):2300-2304
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the anesthesia effects of sevoflurane and propofol in extensive hysterectomy patients and the influence on cognitive function.Methods 94 patients of extensive hysterectomy were selected,according to the drawing method they were divided into control group and observation group,47 cases in each group,the patients were given propofol or sevoflurane anesthesia respectively.The postoperative mini-mental state examination(MMSE) score and the incidence of cognitive dysfunction,inflammation factors,stress reaction,hemodynamic,anesthetic effect and complications were observed in the two groups.Results After operation,the MMSE score of the observation group was higher than that of the control group[(25.44±3.18)points vs.(23.96±2.93)points](t=2.346,P=0.021),the incidence rate of cognitive dysfunction in the observation group was lower than that of the control group [2.12%(1/47) vs.12.76%(6/47)],there was satistically significant difference between the two groups(χ2=3.858,P=0.049 5).The inflammatory factors,stress reaction and hemodynamic index of the observation group were better than those of the control group(all P<0.05).The spontaneous breathing recovery time,open time,extubation time of the observation group were less than those of the control group [(6.19±0.77)min vs.(8.75±1.09)min,(6.89±0.86)min vs.(9.36±1.17)min,(9.47±1.18)min vs.(11.26±1.43)min],there were satistically significant differences between the two groups(t=13.150,11.661,6.619,P=0.000,0.000,0.000).The complication rate had no difference between the two groups(P>0.05).Conclusion The effect of sevoflurane on cognitive function in patients with extensive hysterectomy is less than propofol,and the anesthesia effect is more precisely.
