Effects of laparoscopic distal gastrectomy on serum IL-2 and IL-4 levels in patients with advanced gastric cancer
10.3760/cma.j.issn.1008-6706.2017.15.024
- VernacularTitle:腹腔镜远端胃大部切除术对进展期胃癌患者血清白细胞介素2、4的影响
- Author:
Qingyan YANG
- Keywords:
Stomach neoplasms;
Laparoscopy;
Interleukin-2;
Interleukin-4
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(15):2338-2342
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of laparoscopic distal gastrectomy on serum interleukin-2(IL-2) and interleukin-4(IL-4) levels in patients with advanced gastric cancer.Methods 142 patients with advanced gastric cancer were randomly devided into the control group(71 cases) and the observations group(71 cases) according to the table.The control group was treated with open surgery,while the observation group was treated with laparoscopy.The operation time,intraoperative blood loss,incision length,number of lymphnode dissection,postoperative pain score,average postoperative hospital stay were recorded in the two groups.The serum IL-2 and IL-4 levels were measured before operation and 24 h,36 h after operation.Results The operation time,intraoperative blood loss,incision length,number of lymph node dissection,postoperative anal exhaust time,postoperative pain score,postoperative hospitalization days of the control group were (141.3±29.7)min,(177.6±26.8)mL,(13.2±2.8)cm,(18.1±2.6),(5.9±1.6)d,(8.5±2) and (15.9±3.3)d,respectively,which of the observation group were (196.4±31.6)min,(100.7±21.3)mL,(5.9±1.6)cm,(17.9±2.8),(3.0±1.1)d,(5.2±1.6) and (10.5±1.9)d,respectively.The operation time of the observation group was significantly longer than that of the control group (t=3.264,P<0.05).The amount of intraoperative blood loss,incision length,postoperative anal exhaust time,postoperative pain score,average postoperative hospital stay of the observation group were significantly less than those of the control group (t=4.779,4.069,2.916,3.142,6.904,all P<0.05).There was no significant difference in the number of lymph node dissection between the two groups (t=1.076,P>0.05).In the control group,the IL-2 levels of preoperation and 24h,36h,72h postoperation were (87.26±4.63)μg/mL,(51.26±3.31)μg/mL,(62.18±4.08)μg/mL,(71.66±3.81)μg/mL,respectively,which of the observation group were (87.01±3.91)μg/mL,(69.82±3.09)μg/mL,(80.14±4.24)μg/mL and (82.26±3.47)μg/mL,respectively.There was no significant difference in serum IL-2 level between the two groups (t=0.548,P>0.05).The postoperative serum IL-2 was significantly reduced,and the serum IL-2 levels of postoperative 24h,36h,72h of the observation group were significantly higher than those of the control group (t=3.926,4.867,3.019,all P<0.05).There was no significant difference in serum IL-4 level between the two groups (t=0.416,P>0.05).Postoperative serum IL-4 level was significantly reduced,and the serum IL-4 level of postoperative 24h,36h,72h of the observation group were significantly higher than those of the control group (t=4.012,4.114,3.726,all P<0.05).Conclusion Laparoscopic distal subtotal gastrectomy for advanced gastric cancer patients has less trauma,less immunosuppression,it is conducive to postoperative recovery.
