Research progresses of the effective mechanism of pyroptosis and its related diseases
10.16571/j.cnki.1008-8199.2017.06.020
- VernacularTitle:细胞焦亡效应机制及相关疾病研究进展
- Author:
Qian LEI
;
Tao YI
- Keywords:
Pyroptosis;
GSDMD;
Pore-forming protein;
Autoinflammatory diseases;
Autoimmune diseases
- From:
Journal of Medical Postgraduates
2017;30(6):648-652
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis is a newly discovered form of programmed cell death, which has a close relationship with infectious diseases and spontaneous inflammatory disease and autoimmune disease.Gasdermin-D is the effector of pyroptosis.Inflammatory caspases cleave Gasdermin-D, break the structural autoinhibition and active the pore-forming activity of Gasdermin-D.Gasdermin-D-N domain is the active form of Gasdermin-D.Oligomerized Gasdermin-D-N domain forms membrane pores.Both pyroptosis and necroptosis can form pores.In this article, the progress of the research on pyroptosis, the involvement of Gasdermin-D in the molecular mechanism of pyroptosis, the distinguishment of pyroptosis from necroptosis and pyroptosis-related diseases are reviewed.
