Effects of CaMKⅡ on atrial remodeling during oxidative stress
10.3969/j.issn.1000-4718.2017.06.030
- VernacularTitle:CaMKⅡ在氧化应激中对心房重构的影响
- Author:
Lu HAN
;
Juxiang LI
- Keywords:
Calcium/calmodulin-dependent protein kinase Ⅱ;
Atrial fibrillation;
Atrial remodeling
- From:
Chinese Journal of Pathophysiology
2017;33(6):1138-1140,1152
- CountryChina
- Language:Chinese
-
Abstract:
Atrial structural remodeling and electrical remodeling are the core of atrial fibrillation.Oxidative stress directly activates calcium/calmodulin-dependent protein kinase Ⅱ (CaMKⅡ), and induces electrical remodeling and atrial structural remodeling characterized by reduced atrial effective refractory period, which becomes the pathological basis of atrial fibrillation.Therefore, the study of the relationship between the oxidative CaMKⅡ and atrial remodeling will help to elucidate the pathogenesis of atrial fibrillation and to prevent or reverse atrial remodeling by lowering CaMKⅡ phosphorylation to reduce the incidence of atrial fibrillation.
