Research on inhaled corticosteroid therapy affects the serum proteome of patients with asthma

VernacularTitle:激素吸入疗法对哮喘患者血清蛋白质组影响的研究
Author: Changan WU ; Mingfeng ZHANG
Keywords: asthma; proteomics; inhaled corticosteroids
From: Chinese Journal of Biochemical Pharmaceutics 2017;37(6):63-64,66
CountryChina
Language:Chinese
Abstract: Objective Compare and analyze the serum proteomics data of healthy human and patients with bronchial asthma(both before and after ICS treatment).Then explore the possible pathogenesis and therapeutic targets.MethodsSelect 102 patients with chronic persistent asthma who were diagnosed and treated in our hospital during December 2015 to December 2016, and recruit 102 cases of healthy volunteers over the same period.The patients were treated with conventional ICS, after 8 weeks of treatment, compare and analyzethe serum proteomics data of healthy people and both patients with bronchial asthma (both before and after treatment).ResultsAfter treatment, patients with asthma still got poorer lung function than normal ones (P<0.05);at the same time, all of the serum HSP70, Eotaxin, MMP-9 of pre-treatment patients were higher than healthy individuals (P<0.05), although they had declined after treatment (P<0.05), but still higher than normal people(P<0.05).ConclusionHuman serum HSP70, Eotaxin, MMP-9 may not only be involved in the pathogenesis progress of asthma, but the mechanisms of treating asthma with ICS.