To observe the effects of hip replacement early postoperative cognitive dysfunction by dexmedetomidine
10.3969/j.issn.1005-1678.2017.06.067
- VernacularTitle:右美托咪定对患者髋关节置换术后早期认知功能的影响观察
- Author:
Xiangming LI
- Keywords:
dexmedetomidine given;
hip replacement;
early postoperative cognitive dysfunction
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(6):180-182
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of hip replacement early postoperative cognitive dysfunction by dexmedetomidine.Methods73 were admitted hip arthroplasty patients from January 2015 to February 2016,randomized, double-blind divided into observation group of 36 cases and a control group of 37 cases.Observe patients before anesthesia intravenous infusion dexmedetomidine given treatment, while the control group were given normal saline infusion, patients received general anesthesia program.Mini-Mental State Examination was observed before and after comparison of two groups of patients (MMSE), central nervous system specific proteins at different times (S100β) level, the third day of neuropsychological test function deterioration.ResultsThe patients in the observation group third and seventh days MMSE scores were higher, compared to the difference between the two groups was significant (P<0.05);and the third day after the seventh day S100β level observation group patients They were lower than the control group, compared to the difference between the two groups was significant (P<0.05);the third day POCD postoperative patients in the observation group was 13.89%, significantly lower than the control group, 48.72% (P<0.05);③ observed after patients total effective rate was 92.86%, significantly higher than 35.14% (P<0.05).ConclusionDexmedetomidine given to patients after hip replacement early cognitive function have a more significant improvement, it can reduce the incidence of POCD.
