Clinical observation of Zhisou Huatan capsules combined with levofloxacin in the treatment of acute exacerbations of chronic bronchitis
10.3969/j.issn.1005-1678.2017.06.097
- VernacularTitle:止嗽化痰胶囊联合左氧氟沙星治疗慢性支气管炎急性发作的临床观察
- Author:
Xiangming ZHANG
;
Genliang WANG
- Keywords:
levofloxacin;
bronchitis;
pulmonary function;
cytokine
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(6):259-261
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate zhisouhuatan capsule combined with levofloxacin in the treatment of patients with acute exacerbation of chronic bronchitis.MethodsRetrospective analysis was used to analysis the clinical data of patients with acute exacerbations of chronic bronchitis treated in our hospital from February 2015 to December 2016,according to the treatment methods, which were divided into levofloxacin treatment group and zhisouhuatan capsule combined with levofloxacin in the treatment group.After 4 weeks treatment, the symptom scores, lung function, inflammatory cytokine levels and side effects of the two groups were observed before and after treatment.ResultsThe symptom score of the two groups of patients before treatment had no difference, after treatment, the cough, expectoration and lung auscultation score of combined treatment group were lower than levofloxacin group (t=9.039, 3.574, 7.962, P<0.001);There was no difference between the two groups before treatment.After treatment, the levels of FEV1, FEV1/FVC, MMEF, PEF and FVC in the combined treatment group were higher than that in the levofloxacin group;There was no difference in serum inflammatory cytokine levels between the two groups before treatment.After treatment, the levels of IL-8, hs-CRP and TNF-in the combined treatment group were lower than that in the levofloxacin group (t=25.301, 3.615, 5.733, P<0.001);After 4 weeks of treatment, the blood and urine test results showed that the two groups of patients were not out of liver and kidney dysfunction, with good safety.ConclusionZhisouhuatan capsule combined with levofloxacin on acute exacerbation of chronic bronchitis has good curative effect, can significantly improve symptoms and pulmonary function of patients, with clinical application value.
