Protective roles of fibroblast growth factor-21 on cardiovascular diseases

VernacularTitle:成纤维细胞生长因子21在心血管疾病中的保护作用
Author: Chao DENG
Keywords: Fibroblast growth factor 21; Cardiovascular disease; Atherosclerosis; Myocardial ischemic injury; Cardiac hypertrophy; Diabetic cardiomyopathy
From: Journal of Medical Postgraduates 2017;30(6):661-664
CountryChina
Language:Chinese
Abstract: Fibroblast growth factor 21 (FGF21) is regarded as an important metabolic regulator playing a therapeutic role in diabetes and its complications.Recently, growing evidence showed that heart is a key target as well as a source of FGF21 which is involved in heart development and also induces beneficial effects in cardiovascular diseases.Strong evidences showed that the development of cardiovascular diseases including atherosclerosis, atherosclerosis, coronary heart disease, myocardial ischemia, cardiac hypertrophy, and diabetic cardiomyopathy is associated with increased serum FGF21 levels which was regarded as a compensatory response to induced cardiac protection.This review tries to illuminate the underlying relationship between FGF21 and cardiovascular diseases and the possible mechanisms.