The advancement of microRNA regulating epithelial-mesenchymal transition in cholangiocarcinoma

VernacularTitle:microRNAs调控上皮间质转化影响胆管癌侵袭转移的研究进展
Author: Hua QIU ; Deng XIANG
Keywords: Cholangiocarcinoma; Epithelial-mesenchymal transition; miRNA; Invasion and metastasis
From: Journal of Medical Postgraduates 2017;30(6):665-668
CountryChina
Language:Chinese
Abstract: Cholangiocarcinoma is a highly malignant tumor which originates from bile duct epithelial cells, and its invasion and metastasis is an important factor affecting the prognosis of patients and the main causes of the high mortality.Epithelial-mesenchymal transition is a reversible biological process of transition from epithelial phenotype to stromal cell phenotype, which is closely related to tumor invasion and metastasis.The microRNA is an endogenous non-coding RNA with a sequence of 20~25 nucleotides, which participates in the occurrence and development of tumor, especially in the progress of tumor invasion and metastasis by complementary base pairing with the 3'-untranslated region (3'-UTR) of the target gene at the post-transcriptional level.Herein, we present the mechanism of microRNA regulating epithelial-mesenchymal transition and its effect on the invasion and metastasis of cholangiocarcinoma.