The research progress of relationship between endoplasmic reticulum stress and hepatocellular carcinoma
10.16571/j.cnki.1008-8199.2017.06.025
- VernacularTitle:内质网应激与肝癌关系的研究进展
- Author:
Sheng WANG
- Keywords:
Endoplasmic reticulum;
Endoplasmic reticulum stress;
Unfolded protein response;
Apoptosis;
Hepatocellular carcinoma
- From:
Journal of Medical Postgraduates
2017;30(6):669-672
- CountryChina
- Language:Chinese
-
Abstract:
The process of unfolded or misfolded proteins accumulated in the endoplasmic reticulum lumen termed endoplasmic reticulum stress (ERS), which can result in a variety of prevalent disease, such as autoimmune diseases, neurodegenerative diseases, metabolic disorders and cancer.In order to alleviate the pressure of ERS, eukaryotic cells produce a kind of adaptive intracellular signaling pathway which we called unfolded protein response (UPR, which main role is to remove misfolded proteins and restore endoplasmic reticulum homeostasis.However, apoptosis will be trigger if ERS increases continuously.There are many endoplasmic reticulum in Liver cells, the development of liver cancer is closely related to ERS and apoptosis.Therefore, finding a new method for the treatment of liver cancer in theory from the ERS induced apoptosis pathway seems so meaningful.
