Piceatannol inhibits prostate cancer cell proliferation, migration and invasion
10.3969/j.issn.1000-4718.2017.06.028
- VernacularTitle:白皮杉醇抑制前列腺癌细胞株增殖、迁移与侵袭
- Author:
Zhangchun LI
;
Po LI
;
Chaonan DENG
;
Heng LUO
- Keywords:
Piceatannol;
Cell viability;
Cell migration;
JAK2/STAT3 signaling pathway
- From:
Chinese Journal of Pathophysiology
2017;33(6):1130-1133
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the effect of piceatannol on the viability, and the abilities of migration and invasion in the prostate cancer cells.METHODS:DU145 cells were treated with piceatannol at different doses (0, 5, 10, 20, 40 and 80 μmol/L) for different time (12, 24, 36 and 48 h) as indicated.The cell viability was assessed by CCK-8 assay.The migration and invasion abilities of the cells were analyzed by wound healing assay and Transwell assay, respectively.The protein levels of p-JAK2 and p-STAT3 were detected by Western blot.RESULTS:Piceatannol dose-dependently decreased the cell viability.After treatment with piceatannol, the abilities of migration and invasion of the cells were significantly inhibited.Moreover, treatment with piceatannol resulted in marked decreases in the protein levels of p-JAK2 and p-STAT3.CONCLUSION:Piceatannol inhibits the viability, migration and invasion of the prostate cancer cells via regulating the JAK2/STAT3 signaling pathway.
