Effect of modified Danggui Shaoyao Powder on the expression of COX-2 and Nrf2 in serum of patients with chloasma
10.3969/j.issn.1005-1678.2017.06.034
- VernacularTitle:加味当归芍药散对黄褐斑患者血清COX-2及Nrf2表达水平的影响
- Author:
Xinmin CAO
;
Guoqi WEI
- Keywords:
chloasma;
modified danggui shaoyao powder;
COX-2;
Nrf2
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(6):94-96
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the curative effect of modified Danggui Shaoyao Powder in the treatment of patients with chloasma and the effect on the expression of cyclooxygenase-2 (COX-2) and nuclear factor E2 (Nrf2) in serum.Methods90 cases of patients with chloasma treated in the hospital were selected as the subjects.According to different treatment methods, the patients were divided into the control group (treated with routine western medicine, n=48) and the study group (treated with modified Danggui Shaoyao Powder, n=42).The clinical efficacy, changes of cytokines (serum COX-2 and Nrf2), patch pigment regression.ResultsAfter treatment, the total effective rate of the study group was significantly higher than that of the control group (90.48% vs 72.92%) (P<0.05).After treatment, COX-2, patch pigment regression scores in the two groups were significantly lower than those before treatment, and Nrf2 was significantly higher than that before treatment.The changes were more significant in the observation group than the control group (P<0.05).ConclusionModified Danggui Shaoyao Powder is significant effective in the treatment of chloasma.It can effectively promote the regression of pigment, reduce the skin lesion area and improve the quality of life of patients.The mechanisms may be related to effectively reducing COX-2 and increasing Nrf2.
