Comparative analysis of sedative effects and pharmacoeconomic profiles mediated by two kinds of combination of dexmedetomidine in traumatic brain injury patients
10.3969/j.issn.1005-1678.2017.06.059
- VernacularTitle:右美托咪啶两种联合用药方案对颅脑损伤患者镇静作用及药物经济学比较研究
- Author:
Jin LI
;
Meizhen LI
;
Pan WANG
- Keywords:
dexmedetomidine;
propofol;
midazolam;
traumatic brain injury;
sedation
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(6):158-160
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the sedative effects and pharmacoeconomic profiles of two kinds of combination of dexmedetomidine in traumatic brain injury patients.Methods94 cases of traumatic brain injury from February 2015 to September 2016 were selected and randomly divided into two groups including A group(47 patients) and B group(47 patients).All patients received the same nursing intervention before and after operation.Patients in group A were given right of dexmedetomidine combined with propofol drug therapy, patients in group B were given dexmedetomidine combined with midazolam drug treatment.To maintain the agitation score (SAS) in the standard state of two~four and efficiency of sedation, the mean arterial pressure (map), respiratory rate (RR), heart rate (HR), oxygen saturation (SpO2), arterial carbon dioxide partial pressure (PaCO2), central venous pressure (CVP) Glasgow Coma Score (GCS) and pharmacoeconomic profiles were tested in all patients.ResultsAll patients in two groups achieved the expected sedative effect and analgesia scores.However, A group showed a greater decrease in MAP, RR and HR after sedation as compared to B group.In two groups, there was no significant difference was observed in pulse oxygen saturation (SpO2),partial pressure of carbon dioxide in artery(PaCO2), central venous pressure(CVP)or GCS score before and after sedation.Dexmedetomidine combined with MI of alprazolam treatment phase compared with dexmedetomidine and propofol regimen is more economical, and the difference has statistical significance (P<0.05).ConclusionThe effects of dexmedetomidine combined with propofol and dexmedetomidine combined with midazolam two regimens can achieve good sedative effect.But combined with propofol group compared to midazolam combined with group of respiratory and circulatory system have better inhibitory effect, also in drug economics angle, midazolam midazolam combined with group than that of propofol combined with group is more economical, patients taking lower cost.
