Analysis on the effect of alprostadil on serum UAER, SCr, TNF-α and hs-CRP in patients with diabetic nephropathy

VernacularTitle:前列地尔对糖尿病肾病血清UAER、SCr、TNF-α及hs-CRP水平变化影响分析
Author: Junjiang HAN
Keywords: alprostadil; diabetic nephropathy; inflammatory response; oxidative stress
From: Chinese Journal of Biochemical Pharmaceutics 2017;37(6):353-355
CountryChina
Language:Chinese
Abstract: Objective to investigate the effects of alprostadil on the levels of UAER, SCr, TNF-alpha and hs-CRP in patients with diabetic nephropathy (DN).Methods110 cases with DN from January 2014 to December 2015 in Dagang hospital Tianjin Binhai New Areawere randomly divided into the alprostadil group(basic treatment+alprostadil) and the control group (basic treatment), 55 cases in each group.The clinical effect and the indexes of inflammatory reaction and oxidative stress were compared in the two groups.ResultsAfter treatment, UAER, 24h urinary protein, serum MDA, 8-OHdG, TNF-α, IL-18, ICAM-1, hs-CRP in the alprostadil group were lower than those in the control group (P<0.05);serum SOD, GSH-Px levels in the alprostadil group were higher than those in the control group (P<0.05).The total effective rate of diabetic nephropathy in alprostadil group (92.73%) was significantly higher than that in control group (74.55%), the data were compared with(P<0.05).ConclusionIt has a positive effect on improving the therapeutic effect which alprostadil in the treatment of patients with DN, and it can relieve the inflammatory reaction and oxidative stress injury.