Study of NT-1 in Promoting the Recovery Mechanism in MCAO Model
10.3969/j.issn.1671-332X.2017.05.026
- VernacularTitle:Netrin-1促进脑缺血康复的作用机制研究
- Author:
Chunyun LUO
;
Xiaosong HE
- Keywords:
NT-1;
Cerebral Ischemia/Cerebral Occlusion;
Angiogenesis;
Apoptosis
- From:
Modern Hospital
2017;17(5):710-712,715
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the study of NT-1 promote recovery mechanisms after cerebral ischemia.Methods 30 ICR mice were equally divided into NT-1 and BSA groups and respectively given NT-1 and BSA injection in the brain.The middle cerebral artery ischemia model was established with suture method.NRSS score and beam-walking test were used to exam the behavior performance after MCAO.Immnuohischemstry was used to evaluate the status of angiogenesis and apoptosis.Results Compared to the BSA group, NT-1 not only reduced the time on the beam-walking but the score of NRSS behavioristices.NT-1 also increased the number of vessels and reduced the number of apoptotic cells.Conclusion NT-1 cerebral injection can promote the recovery by increasing angiogenesis and inhibiting apoptosis.NT-1 is a promise target in the treatment of cerebral ischemia.
