Correlations between BDNF genetic polymorphism and postpartum depression in cesarean section parturient
10.11855/j.issn.0577-7402.2017.06.11
- VernacularTitle:BDNF基因多态性与剖宫产产妇产后抑郁的相关性分析
- Author:
Yingyong ZHOU
;
Saiying WANG
;
Mi YANG
;
Zhendong HUANG
;
Jiahui MA
;
Kaiming DUAN
- Keywords:
postpartum depression;
genetic polymorphism;
brain-derived neurotrophic factor;
Edinburgh postpartum depression scale
- From:
Medical Journal of Chinese People's Liberation Army
2017;42(6):538-544
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlations between the genetic polymorphism of brain-derived neurotrophic factor (BDNF) and the postpartum depression (PPD) in cesarean section parturient. Methods Three hundred and sixty parturients, who underwent cesarean section under spinal anesthesia from Feb. 2014 to Feb. 2015 in Third Xiangya Hospital of Central South University or Hunan Maternal and Child Health Hospital, were selected as subjects. The general information of parturients was recorded and Edinburgh Postnatal Depression Scale (EPDS) was used to evaluate the depression condition of parturients at the prenatal 1 day and the 42th day postpartum, and with a cut-off point of 12/13 for identifying PPD. The genotypes of BDNF gene locus G712A, rs56164415, rs11030100, rs11030101 and rs6265 were measured by Sequenom? Mass Array SNP. Finally, the correlations of PPD to different genotypes and general information of parturients were statistically analyzed. Results The incidence of PPD among the selected subjects was 7.2%. Pregnancy mental stress, poor pregnancy mood, perinatal elevated monocyte count, prenatal depression mood and BDNF gene locus rs6265 mutation all could affect the incidence of PPD in cesarean section parturients (P<0.05). No statistically significant difference existed between BDNF gene G712A, rs11030101, rs11030100 and rs56164415 locus mutation and PPD (P>0.05), and their haploid forms were not related to PPD also. Conclusion BDNF rs6265CC genotype, pregnancy mental stress, poor pregnancy mood, perinatal elevated monocyte count and prenatal depression mood are the risk factors for postpartum depression.
