Preparation and Formulation Optimization of Nanostructured Lipid Carriers of Adefovir Dipivoxil
10.6039/j.issn.1001-0408.2017.16.27
- VernacularTitle:阿德福韦酯纳米脂质载体的制备及处方优化
- Author:
Shanshan SUN
;
Huiyun WANG
;
Feifei WANG
;
Lin DING
- Keywords:
Adefovir dipivoxil;
Nanostructured lipid carrier;
Gemini surfactant;
Formulation optimization
- From:
China Pharmacy
2017;28(16):2259-2261
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare nanostructured lipid carrier of adefovir dipivoxil(ADV-NLC),and optimize the formula-tion. METHODS:Using stearic acid and glycerin monostearate as solid lipid,oleic acid as liquid lipid,Gemini surfactant and poly-sorbate 80 as emulsifier,sodium dodecyl sulfate (SDS) as stabilizer,solvent dispersion ultrasonic method was used to prepare ADV-NLC. And using particle size,polydispersity index,Zeta potential,encapsulation efficiency as indexes,single factor test was conducted to screen Gemini surfactant-polysorbate 80 ratio,emulsifier dosage(ratio of emulsifier to water phase),drug-lipid ratio, solid-liquid lipid ratio. RESULTS:The formula was as follow as 3% emulsifier (Gemini surfactant-polysorbate 80 ratio of 1:2), 4.5% drug-lipid ratio,solid-liquid lipid ratio of 6:5. The average particle size of the prepared ADV-NLC was(48.83±2.65)nm, polydispersity index<0.3,Zeta potential was(-28.7±1.8)mV,encapsulation efficiency was(77.65±0.03)%(n=3). CONCLU-SIONS:ADV-NLC is successfully prepared,and the formulation is reasonable and feasible.
