Relationship between preoperative FIB-4 and hepatocellular carcinoma prognosis after curative resection
10.3969/j.issn.1000-8179.2017.10.185
- VernacularTitle:术前FIB-4评分与肝细胞癌术后患者预后的关系研究
- Author:
Xiaoyong LUO
;
Chengyou DU
;
Xiong YAN
;
Dewei LI
;
Ming LI
;
Qiao WU
;
Rui LIAO
- Keywords:
hepatocellular carcinoma;
liver cirrhosis;
FIB-4;
hepatitis B virus;
prognosis
- From:
Chinese Journal of Clinical Oncology
2017;44(10):498-501
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the correlation between FIB-4 and the clinicopathological characteristics and prognosis of patients with hepatocellular carcinoma (HCC) after curative resection. Methods: From January 2009 to December 2012, the clinicopathological and follow-up data of 245 patients with HCC after curative resection were retrospectively studied. Their survival was calculated using the Kaplan-Meier method. The Cox proportional hazard regression model was used for the multivariate analysis. Results: According to FIB-4 index, patients were divided into two subgroups: FIB-4Ⅰ(≤3.25) and FIB-4Ⅱ(>3.25). FIB-4 could predict liver cirrhosis severity (Ishak grade, Grade 1-5 vs. Grad 6, r=0.681, P<0.001). It was associated with liver function such as:aspartate transaminase (P<0.001)、total bilirubin (P=0.009)、albumin (P=0.001) and platelet count (P<0.001) other than tumor clinicopathologic features. Both univariate and multivariate analysis showed FIB-4 could predict the prognosis of HCC patients (Overall survival: P=0.037 and 0.011; Recurrencefree survival: P=0.027 and P=0.043, respectively). Conclusion: The preoperative FIB-4 index could be used as a prognostic marker for the prognosis of HCC after curative hepatectomy.
