Current understanding of ABCA1 in lipid accumulation
- VernacularTitle:ABCA1在脂质沉积中的研究进展
- Author:
Zixiang DENG
;
Zhong ZUO
- Keywords:
ABCA1;
lipids;
microRNAs
- From:
Basic & Clinical Medicine
2017;37(6):869-873
- CountryChina
- Language:Chinese
-
Abstract:
ATP-binding cassette transporter A1 (ABCA1) is an membrane protein,using ATP for transferring substances,modulated by liver X receptors(LXRs), retinoic X receptors(RXRs), sterol regulatory element binding proteins(SREBPs), microRNAs and other upstream modulators.ABCA1 plays an important role in multiple pathways related to lipid accumulation.Upregulating ABCA1 expression may slow-down lipid accumulation, thus offers a promising strategy for metabolic diseases.
