Effect of pulmicort respules inhalation combined with tulobuterol in treating infantile asthmatic pneumonia and its effect on serum inflammatory factors
10.3760/cma.j.issn.1008-6706.2017.15.017
- VernacularTitle:布地奈德混悬液雾化吸入联合妥洛特罗贴剂治疗小儿喘息性肺炎的疗效及其对炎性因子的影响
- Author:
Mengmeng ZHONG
- Keywords:
Pneumonia;
Administration;
inhalation;
Child;
Pulmicort respules;
Trotolol
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(15):2308-2312
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of atomized inhalation of pulmicort respules combined with tulobuterol in the treatment of children with wheezing pneumonia and its influence on serum inflammatory factors.Methods 90 children with asthmatic bronchopneumonia were selected,and they were randomly divided into observation group and control group,45 cases in each group.The control group received routine western medicine and atomized inhalation of ambroxol hydrochloride.The observation group was treated with pulmicort respules inhalation combined with tulobuterol paste service on the basis of the control group.After 1 course of treatment,the efficacy was evaluated.The improvement of clinical symptoms,clinical efficacy,serum cytokine level,inflammatory index and adverse reaction were compared between the two groups.Results The disappearance time of clinical signs such as shortness of breath,cough,wheezing and pulmonary rales in the observation group were significantly shorter than those in the control group [(7.58±0.72)d,(8.42±1.33)d,(5.66±0.74)d,(7.76±0.75)d vs.(4.21±0.29)d,(2.59±0.71)d,(3.41±0.69)d,(5.29±0.71)d,P<0.01],and there were statistically significant differences between the two groups(t=29.124,25.940,14.913,16.044,all P<0.05).The total effective rate in the observation group was 93.3%,which was significantly higher than 80.0% in the control group(χ2=5.214,P<0.01).There was no significant difference in the ECP and Eos levels between the two groups before treatment(P>0.05).The ECP and Eos in the peripheral blood of the two groups were significantly lower than those before treatment(t=8.363,4.307,13.431,12.949,all P<0.05).The ECP and Eos of the observation group were significantly lower than those of the control group(t=7.792,5.838,all P<0.05).IL-4,IL-6 and IL-10 in peripheral blood of the two groups before treatment were not significantly different(all P>0.05).After treatment,the levels of IL-4,IL-6 and IL-10 were significantly decreased and the IFN-γ level was significantly higher than before treatment(t=17.216,20.051,17.891,15.417,32.724,26.709,28.112,26.708,all P<0.05).The levels of inflammatory cytokines in the peripheral blood of the observation group were significantly better than those of the control group(t=9.306,4.150,5.117,4.124,all P<0.05).No serious adverse events occurred in the two groups during the treatment.Conclusion Pulmicort respules combined with tulobuterol is effective in the treatment of children with wheezing pneumonia.It can relieve the symptoms of cough and wheezing.The mechanism may be related to the imbalance of Th1/Th2 imbalance and the reduction of airway inflammation.
